The 2nd Workshop on Quantum-Secure Networks and Systems will take place on July 2-5, 2025, in Bologna, Italy and is again a joint initiative of the Qubip and PQ-REACT EU projects. The QSNS2025 workshop will address the most pressing cybersecurity challenges of the quantum era from an engineering perspective, with the aim of contributing to global efforts towards an agile, post-quantum or post-quantum/traditional hybrid and standards-based transition to PQC of the digital infrastructures we all use today.